Yuanyuan Jin, Ph.D., Co-Founder & Chief Operating Officer
B.S. with Honor, Biochemistry, Rowan University, Glassboro NJ, 2007
Ph.D., Molecular Pharmacology and Structural Biology, Thomas Jefferson University, Philadelphia PA, 2016
RESEARCH AND PROFESSIONAL EXPERIENCE:
Co-founder and Chief Operating OfficerBound Therapeutics LLC
January 2015 – Present Philadelphia, PA
• Lead a multidisciplinary team to commercialize proprietary miRNA therapeutics platform technology
• Research and development of multiple lead molecules for the treatment of triple negative breast cancer in the preclinical phase
• Manage and collaborated with Contracted Research Organizations (CROs)
• Secured government funding through Small Business Technology Transfer Grant
• Provide support for patent drafting and patent strategy development
• Leadership, team building, and strategic partnership with bio-tech companies
• Negotiate licensing agreements with Thomas Jefferson University
PhD Candidate, Molecular Pharmacology and Structural Biology, Thomas Jefferson University, Philadelphia, PA, June 2008 – 2016
• Developed a paradigm-shifting platform to block oncogenic miRNAs.
• Discovered miRNA passenger strand activity
• Collaborated with colleagues and other research scientists to develop sequence specific radio-imaging and fluorescence imaging agents for tumors and neuron disease
• Prepared manuscripts and patent related documents
• Mentored rotation students, master students and summer interns
• Presented research work through poster and oral presentations at international conferences
Quality Control Chemist, Baxter Health Care, Cherry Hill, NJ, Fall 2007 – Summer 2008
• Tested raw material precursors for GMP manufacturing to ensure quality
Laboratory Researcher with Dr. Amos Mugweru, Rowan University, Glassboro, NJ, Spring 2007
• Analyzed Mg and Al levels in light bulb filaments from different companies to identify infringement
Laboratory Researcher with Dr. Catherine Yang, Rowan University, Glassboro, NJ, Fall 2006 – Summer 2007
• Purified prostate specific antigen (PSA), characterized active site through mechanism-based inhibition by organophosphate, and studied kinetics with substrates and inhibitors
Laboratory Researcher with Dr. Gregory Hecht, Rowan University, Glassboro, NJ, Summer 2005 – Summer 2006
• Analyzed genetics of lead precipitation by Caulobacter crescentus
Other Experience and Professional Memberships
2023-2024: Member of the American Society of Clinical Oncology
2012-2013: Member of the American Chemical Society
2013-2014: Treasurer, Business and Biotechnology Group, Thomas Jefferson University, Philadelphia PA
• Organized seminar series
• Prepared budgets for organizational events and provide annual cost projection
• Prepared documentation for organizational registration and funding requests
Awards and Recognitions:
Small Business Technology Transfer Grant: microRNA-21 Blockade of Triple Negative Breast CancerNational Cancer Institute
June 2019
JGSBS Alumni Association Graduate Student Travel FellowshipThomas Jefferson University
February 2015Philadelphia, PA
JGSBS Alumni Association Graduate Student Travel FellowshipThomas Jefferson University
November 2011Philadelphia, PA
Medallion Award: Ethel F. Brannan/George Geng World Education AwardRowan University May 2007Glassboro, NJ
Chemistry/Biochemistry Department Research AwardRowan University May 2007Glassboro, NJ
Certificates
2014: The Data Scientist’s Toolbox, Johns Hopkins Bloomberg School of Public Health, Coursera Verified Certificate, License MTWVBBJQJH
2015: R Programming, Johns Hopkins Bloomberg School of Public Health, Coursera Verified Certificate, License 54LW5PQRP6
Patents:
Composition and Methods for MYC Messenger RNA Inhibitors US 11306312
Issued April 19th, 2022
Compositions and Methods for the Treatment of Cancer PCT/US2024/019719
March 13th, 2024
Compositions and Methods for the Treatment of Coronavirus Infection, US 17/470676
September 9th, 2021
Compositions and Methods of Using MicroRNA Inhibitors US PCT/US2015/015681
February 12th, 2015
PUBLICATIONS:
Tripathi SK, Kean R, Bongiorno E, Hooper DC, Jin YY, Wickstrom E, McCue PA, Thakur ML. Targeting VPAC1 Receptors for Imaging Glioblastoma. Mol Imaging Biol. 2020 Apr;22(2):293-302. doi: 10.1007/s11307-019-01388-5. PMID: 31292914.
Jin, Y.-Y., Andrade, J., Simone, N.L., and Wickstrom, E. (2015) Specific blocking of miR-17-5p guide strand in triple negative breast cancer cells, without amplifying passenger strand activity. PLoS One 10(12):e0142574.
Jason Mazzaroth, M.S., Chief Technical Officer
B.S. with Honor, Theoretical and Mathematical Physics, Rowan University, Glassboro NJ, 2005
M.S., Electrical and Computer Engineering, Rowan University, Glassboro NJ, 2013
Ph.D. Candidate, Material Science & Engineering, Rowan University, Glassboro NJ, 2023-present
RESEARCH AND PROFESSIONAL EXPERIENCE:
2019-Present: Ph.D. Candidate, Material Science & Engineering, Rowan University, Glassboro NJ
• Researched electrocatalysis alloy compositions using Machine Learning with Python and Scikit-learn.
• Discovered OER (Oxydation Evolution Reaction) relationships as a function of alloy composition features with Tafel plot and overpotential targets.
2019-Present: Chief Technology Officer, Bound Therapeutics LLC, Cherry Hill NJ
• Invented proprietary artificial intelligence algorithm using Computational Quantum Physics, Bioinformatics, Machine Learning.
• Designed IGF1R binding peptides for receptor-specific drug delivery using proprietary AI algorithm
• Designed anti-viral peptide inhibitors to block SARS-CoV-2 spike protein binding to the angiotensin converting enzyme 2 (ACE-2) receptor.
• Performed Linux System Administration for CUDA.
• Built and implemented RNA-seq pipeline for bioinformatics analysis
2017-2018: Cyber Security Consultant, PixiLudi, LLC, Marlton NJ
• Read cyber security threat documentation for Fortune 500 companies and remediated all threats, whether severe or mild. The technologies that I primarily remediated includes: C#, VB, JavaScript, Python, PHP, SQL, Windows and Linux Networks, and Router security.
2013-2016: Research and Development Programmer, Innovative Software Solutions (ISSI), Maple Shade NJ
• Invented and implemented software solutions for law firms, and medical and pharmaceutical insurance companies in C++, SQL and Python. Using my software inventions, law firms were able to recover billions of dollars in genuine malpractice cases that would otherwise be impossible to find.
• Designed and implemented a data visualization framework for medical and financial summaries.
• Designed and implemented a framework for data mining for subrogation that increased the productivity of the project ninety-fold.
• Worked on large and small teams with a variety of disciplines.
2013: Algorithms Intern, Thomas Jefferson University, Philadelphia PA
• Improved phase one of the Teiresias algorithm by using a combinatorial divide-and-conquer approach (n/lg(n))
• Improved the overall performance further using compiler optimization and analysis.
2011-2013: Graduate Research Assistant, Rowan University, Glassboro NJ
• Team Leader for NJBPU’s Energy Assurance Plan (EAP).
• Managed student engineering team with SWOT Analysis, strategic business management, and Gantt charts on the NJBPU’s EAP (Energy Assurance Plan) project.
• Researched related patents, economic and technical feasibility and safety.
2003-2010: Math/Physics Private Instructor, Rowan University, Gloucester County College, NJ
2002-2005: Laboratory Researcher with Dr. Samuel Lofland, Rowan University, Glassboro NJ
• Researched on Magneto-Optical Kerr Effect (MOKE), Thermodynamic Properties of Magnetic Materials, and Biophysics.
Certificates
2017: Python for Genomic Data Science, Johns Hopkins Bloomberg School of Public Health, Coursera Verified Certificate, License 369N7ALDNPMT
2017: Algorithms for DNA Sequencing, Johns Hopkins Bloomberg School of Public Health, Coursera Verified Certificate, License FLF68GSMOY6H
Patents:
Compositions and Methods for the Treatment of Coronavirus Infection, US 17/470676
September 9th, 2021
PUBLICATIONS:
Lofland, S.E., et al., Multimode near-field microwave monitoring of free water content of skin and imaging of tissue. Phys Med Biol, 2007. 52(5): pp. 1295-1301.